What sort of necrotizing soft tissue infections should we be concerned about in an IV drug user? How is it treated?

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What sort of necrotizing soft tissue infections should we be concerned about in an IV drug user? How is it treated?

Clostridial species and gram positive anaerobes.Tx with penicillin (Clostridial) + clindamycin (anaerobic streptococci and staphylococci) + vancomycin