General characteristics of sickle cell anemia
Autosomal recessive HbA –> HbS (homozygous causes anemia) Substitution of uncharged valine for negative glutamic acid at 6th position of beta chain Hb molecules polymerize in low oxygen conditions
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General characteristics of sickle cell anemia
Autosomal recessive HbA –> HbS (homozygous causes anemia) Substitution of uncharged valine for negative glutamic acid at 6th position of beta chain Hb molecules polymerize in low oxygen conditions