Paget’s disease?,”Paget’s disease affects approximately 3% of adults over age 40. IT is a disorder of increased bone turnover, in which osteoclast dysfunction leads to increased bone breakdown and a compensatory increase in bone formation. The result is a “”mosaic”” pattern of lamellar bone. The pelvis, skull, spine and long bones are most commonly involved. Most patients with Paget’s disease are asymptomatic, identified incidentally by radiographic findings or elevated alkaline phosphatase levels. Symptoms may include skeletal deformities, bone or joint pain, fractures, nerve entrapment

Paget’s disease?,”Paget’s disease affects approximately 3% of adults over age 40. IT is a disorder of increased bone turnover, in which osteoclast dysfunction leads to increased bone breakdown and a compensatory increase in bone formation. The result is a “”mosaic”” pattern of lamellar bone. The pelvis, skull, spine and long bones are most commonly involved. Most patients with Paget’s disease are asymptomatic, identified incidentally by radiographic findings or elevated alkaline phosphatase levels. Symptoms may include skeletal deformities, bone or joint pain, fractures, nerve entrapment

or osteosarcoma. Enlarging cranial bones may lead to an increasing hat size or entrapment of cranial nerve 8 resulting in hearing loss.”