Sos,”(binding site for GRB2 protein)GEF for Ras (which is monomeric G protein)promotes GDP (same thing G coupled protein does)alters the conformations of 2 switch regions to promote GDP releasehas an alpha-helical domain–>displaces switch 2 (pushes down)

Sos,”(binding site for GRB2 protein)GEF for Ras (which is monomeric G protein)promotes GDP (same thing G coupled protein does)alters the conformations of 2 switch regions to promote GDP releasehas an alpha-helical domain–>displaces switch 2 (pushes down)

allowing GDP to diffuse away(now need GEF–>GTP bound–>locks G protein in active conformation)”