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Alfatoxin B1

June 19, 2017 mfadmin Biology

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Alfatoxin B1

potent mutagen and carcinogen (better then most/all…)

Microcell Biology

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Previous Post:Myc,”translocation of c-myc gene from chromosome 8 to 14 places it under transcriptional control of a strong immunoglobulin gene transcriptional enhancer(don’t need growth factor, elevated expression…)overexpression of c-myc in these B cells causes Burkitt’s lymphomagoing to be self-sustaining b/c last step is activatedlast step in RTK signaling before activating Cyclin D (trips the cycle out of G0), transcription activated, make a proteindifficult to target(activate transcription of myc, RNA out of cytoplasm, comes back into nucleus, that activates Cyclin D–>once synthesis begins

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