Cytochrome P-450,”enzymes that modify smoked meat compounds(why liver cancer is so prevalent)liver exposed to higher concentration of these compounds than other organs and tissuesIntestinal epithelial cells (exposed to everything that goes through our bodies)cytochrome P-450 convert, guanine forms covalent adduct that can only be repaired by DNA repair enzymes

Cytochrome P-450,”enzymes that modify smoked meat compounds(why liver cancer is so prevalent)liver exposed to higher concentration of these compounds than other organs and tissuesIntestinal epithelial cells (exposed to everything that goes through our bodies)cytochrome P-450 convert, guanine forms covalent adduct that can only be repaired by DNA repair enzymes

modified base in DNA strand during replication will distort helix and form basepair w/ Adenine instead of Cytosinemost often modified G goesAdduct converts GC to TA”