With exposed regions of DNA…,”only have exposed DNA very transiently during transcription and replicationModified guanine will distort double helix, will be enough to activate themRNA polymerase can’t get through them, going to have exposed regions of DNA single stranded DNA activates kinasesKinases have two main targets to phosphorylate:1) P532) checkpoint 1 or 2Going to see:1) stop cell cycle2) activate expression of gene3) if none work

With exposed regions of DNA…,”only have exposed DNA very transiently during transcription and replicationModified guanine will distort double helix, will be enough to activate themRNA polymerase can’t get through them, going to have exposed regions of DNA single stranded DNA activates kinasesKinases have two main targets to phosphorylate:1) P532) checkpoint 1 or 2Going to see:1) stop cell cycle2) activate expression of gene3) if none work

cause the gene to undergo apoptosis and kill itselfP53 activates transcription of all-purpose CDC inhibitor P21cip”