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What are the differences between sites affected by primary and secondary hemostasis?,”Primary – petechiae, purpura, mucosal bleeds (gingival bleeding, epistaxis, menorrhagia, immediate bleeding)Secondary – Subcutaneous, hemarthrosis, muscle hematoma, GI/GU
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Read moreWhat is the approach to disorders of hemostasis? What is the initial investigations?,”Get a platelet, INR/PTT, determine primary vs secondaryInherited primary – vWB DzInherited secondary – Hemophilia (8/9), Factor 11 deficiencyAcquired primary – Thrombocytopenia, uremia, drugs (HITT), myelodysplastic disordersAcquired secondary – Liver dz, DIC
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Read moreWhat are 5 DDx of acquired primary disorders of hemostasis?
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Read moreWhat infections cause HUS?
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Read moreHow do you treat HUS/TTP?
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Read moreWhat are 4 DDx of acquired secondary disorders of hemostasis?,”1. Liver disease2. Vitamin K deficiency 3. Drugs (warfarin, heparin)4. DIC
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Read moreWhat is the DDx for an isolated elevated PTT?,”HeparinLupus anticoagulant Severe vWD (Factor 8 carrier)Single factor deficiency (12, 11, 9
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Read moreWhat is the DDx for an isolated elevated INR?
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Read moreWhat is the DDx for an elevated INR and PTT?,”Multiple factor deficiencySystemic illness (DIC, Liver dz, Vitamin K deficiency)Drugs (warfarin, high dose heparin, NOAC)Single factor deficiency (10, 5, 2
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