Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Oncogene addiction,”oncogene responsible for allowing[…]
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“HW: Which combination of drugs would most effectively treat a tumor w/ “”sustained proliferative signaling”” & “”replicative immortality”” as its 2 main cancer hallmarks?”
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.“HW: Which combination of drugs[…]
Read moreHW: Which of the following pairs of cancer hallmarks would be most directly eliminated if you could restore p53 function (e.g. with a chaperone therapy) in tumor cells?
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: Which of the following[…]
Read moreVariety of treatments to choose from…,”90% of drugs don’t do anythingvast majority target kinases (ser/thr)problematic: never going to be able to achieve tumor specificity that you wanttypically much more specific
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Variety of treatments to choose[…]
Read moreHW: Which is the largest functional class of protein targets for chemotherapeutic drugs currently in use?
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: Which is the largest[…]
Read moreAngiogenesis,”prevent vascularization by targeting normal epithelial cells?cutting off access to circulatory system; cutting off oxygen, glucose, opportunities for metastasis-all good!but also cutting out means by which drug gets delivered to cancer…cells will actually proliferate more aggressively than they did in the absence of the drugcan make a drug that works too well
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Angiogenesis,”prevent vascularization by targeting normal[…]
Read moreCancer Moonshot
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Cancer Moonshot long list of[…]
Read moreHW: Burkitt’s lymphoma is due to the overexpression of c-myc protein. Chronic myelogenous leukemia (CML) is due to the expression of constitutively active Bcr-Abl protein. What do these two cancers have in common?
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: Burkitt’s lymphoma is due[…]
Read moreHW: What was the basis for finding that Axitinib could be used to treat Gleevec-resistant CML?,”Axitinib is a previously well-characterized and effective VegFR inhibitor that binds with a high affinity to Bcr-Abl (T315I)
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: What was the basis[…]
Read moreP53,”most important tumor suppressorthe weak point of the system-the single point of failure; p53 is protein that links DNA damage to activating the checkpoint throughout the cycle (because DNA damage can occur at any time), stopping the cell cycle, repairing the damage and initiating apoptosis(interactions with ATM kinase, Mdm2, and Chkpoints1&2)In low concentration, p53 stops cell cycle. Damage unstopped b/c don’t activate repair genes (not high enough affinity) damage persists, repair genes activated, cell cycle arrest transientIf inactivated, damage accumulates
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.P53,”most important tumor suppressorthe weak[…]
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