Autoimmune hemolytic anemia
Warm-IgG at 37C –> Extravascular hemolysis –> splenomegaly. Treat with steroidsCold-IgM at 0-5C –> Intravascular hemolysis. Treat by avoiding cold. Steroids are unhelpful*Causes include mycoplasma or infectious mononucleosisDx: Warm –> RBC coated in IgGDx: Cold –> RBC coated in complement