Bcr/Abl,”normally well-behaved kinase called Abl. Comes into Ras. It is a tyrosine kinase that can autophosphorylate when it gets switched on, and can activate Ras w/o an extracellular signal. Can be activated within the cytosol, once phosphorylated it binds…Going down signaling pathway, but starting within the cellAbl normally well regulated
but not when this translocation takes place”