Category: Biology

BIO205

How dominant-negative mutations caused p53 to also be identified as an oncogene,”most p53 mutations eliminate DNA binding and destabilize the protein (mutant protein is functionally “”invisible””)BUT since p53 functions as a tetramer, some mutations that eliminate p53 function (transactivation), also inactivate tetramers containing only 1 mutant subunitIf cells contain equivalent amounts of wild-type and d-n mutant forms of p53 protein

Biology

Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.How dominant-negative mutations caused p53[…]

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Cytochrome P-450,”enzymes that modify smoked meat compounds(why liver cancer is so prevalent)liver exposed to higher concentration of these compounds than other organs and tissuesIntestinal epithelial cells (exposed to everything that goes through our bodies)cytochrome P-450 convert, guanine forms covalent adduct that can only be repaired by DNA repair enzymes

Biology

Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Cytochrome P-450,”enzymes that modify smoked[…]

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With exposed regions of DNA…,”only have exposed DNA very transiently during transcription and replicationModified guanine will distort double helix, will be enough to activate themRNA polymerase can’t get through them, going to have exposed regions of DNA single stranded DNA activates kinasesKinases have two main targets to phosphorylate:1) P532) checkpoint 1 or 2Going to see:1) stop cell cycle2) activate expression of gene3) if none work

Biology

Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.With exposed regions of DNA…,”only[…]

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