Pharmacologic management of Prinzmetal’s angina?,”Variant angina (Prinzmetal’s angina) causes chest pain by coronary vasospasm. It typically occurs in young females, and the greatest risk factor for variant angina is smoking. The treatment for this condition involves elimination of risk factors such as smoking

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Ankylosing spondylitis?,”AS usually occurs at age <40 and presents with gradual onset of low back pain. The pain improves with exercise (rather than rest) and can be associated with hip or buttock pain. Other possible findings include anterior uveitis and enthesitis (inflammation of tendon insertion site at bone). AS is an inflammatory disorder that involves primarily the apophyseal (facet) joints of the axial skeleton. Patients with suspected AS require measurement of inflammatory markers (eg, ESR, CRP), HLA-B27 typing

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Hyperthyroidism?,”Plasma TSH is the best initial diagnostic test for patients with suspected hyperthyroidism. Almost all patients with hyperthyroidism have low TSH concentrations due to appropriate suppression by high serum T3/T4 concentrations. If the plasma TSH level is low, free plasma T4 should be measured, and if this is elevated, the diagnosis of clinical hyperthyroidism is established. A 24-hour thyroid radioiodine uptake and scan should be done to differentiate Grave’s hyperthyroidism from other causes. In the management of patients with hyperthyroidism

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Tricyclic antidepressant (TCA) overdose?,”TCA overdose can have central nervous system toxicity )eg, sedation, seizures, coma), anticholinergic toxicity (eg, hyperthermia, dilated pupils, intestinal ileus, urinary retention), and cardiac toxicity. Cardiac toxicity causes most death in TCA overdose. Sodium bicarb is used to treat cardiac toxicity, which is characterized by prolonged QRS duration and ventricular arrhythmias. Sodium bicarb increases serum pH and extracellular sodium

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