Checkpoints 1 and 2
inhibit Cdc25cells using Wee1 to make a DNA damage checkpointcan also be phosphorylated by ATM kinasecan also phosphorylate p53 (but check2 cannot activate Mdm2…only ATM can)they both have primary target Cdc25 (which is necessary to dephosphorylate tyrosine 15)Phosphorylation of tyrosine 15 also stops cdc from working