Clinical diagnosis of Parkinson’s disease?,”1. Tremor:- A resting 4-6 Hz tremor with a “”pill rolling”” quality- Frequently first manifests in one hand, and may then slowly generalize to involve the other side of the body and the lower extremities2. Rigidity:- Baseline increased resistance to passive movement about a joint3. Bradykinesia:- Difficulty initiating movements, as when starting to walk or rising from a chair- Narrow-based, shuffling gait with short strides and without arm swing- Micrographia (small handwriting)- Hypomimia (decreased facial expression)- Hypophonia (soft speech)4. Postural instability:- Flexed axial posture- Loss of balance during turning or stopping- Loss of balance when pushed slightly from a stationary bipedal stance- Frequent falls The 3 cardinal signs of Parkinson disease are rest tremor, rigidity
and bradykinesia. The presence of at least 2 of these signs on PE is grounds for clinical diagnosis of this disease.”