“HW: Cetuximab binds to the EGF receptor (EGFR) and it’s initially effective in treating certain metastatic colon cancers when combined with radiation or other chemotherapies. However, over time, these tumor cells frequently become resistant to Cetuximab treatment. Which of the following mutational events is most frequently associated w/ the emergence of Cetuximab resistance?”,”Any one of G11
G12 or Q61 on Ras is converted to X”