HW: What was the basis for finding that Axitinib could be used to treat Gleevec-resistant CML?,”Axitinib is a previously well-characterized and effective VegFR inhibitor that binds with a high affinity to Bcr-Abl (T315I)

HW: What was the basis for finding that Axitinib could be used to treat Gleevec-resistant CML?,”Axitinib is a previously well-characterized and effective VegFR inhibitor that binds with a high affinity to Bcr-Abl (T315I)

but not Bcr-Abl (T315)”