Multi-Hit Model,”Cancer is a disease of aging. It’s not a disease that affects the young people (rare)bottom graph: how many days during the life of the mouse it’ll go through while tumor freeMyc mice relatively tumor free after 120 days, then gradual decline in # of tumor free individualsCompared to Ras, finding that mice that harbor Ras oncogene start acquiring tumors much, much earlierIf cross two strains, now have mice that have both oncogenes. Ras operating much further upstream than Myc. When put together, get synergistic effect, causing rapid onset of tumorigenesis

Multi-Hit Model,”Cancer is a disease of aging. It’s not a disease that affects the young people (rare)bottom graph: how many days during the life of the mouse it’ll go through while tumor freeMyc mice relatively tumor free after 120 days, then gradual decline in # of tumor free individualsCompared to Ras, finding that mice that harbor Ras oncogene start acquiring tumors much, much earlierIf cross two strains, now have mice that have both oncogenes. Ras operating much further upstream than Myc. When put together, get synergistic effect, causing rapid onset of tumorigenesis

and all mice that harbor two oncogenes are going to be dead in 150 days. combined effects aren’t additive-almost exponential in collaboration”