P53,”most important tumor suppressorthe weak point of the system-the single point of failure; p53 is protein that links DNA damage to activating the checkpoint throughout the cycle (because DNA damage can occur at any time), stopping the cell cycle, repairing the damage and initiating apoptosis(interactions with ATM kinase, Mdm2, and Chkpoints1&2)In low concentration, p53 stops cell cycle. Damage unstopped b/c don’t activate repair genes (not high enough affinity) damage persists, repair genes activated, cell cycle arrest transientIf inactivated, damage accumulates

P53,”most important tumor suppressorthe weak point of the system-the single point of failure; p53 is protein that links DNA damage to activating the checkpoint throughout the cycle (because DNA damage can occur at any time), stopping the cell cycle, repairing the damage and initiating apoptosis(interactions with ATM kinase, Mdm2, and Chkpoints1&2)In low concentration, p53 stops cell cycle. Damage unstopped b/c don’t activate repair genes (not high enough affinity) damage persists, repair genes activated, cell cycle arrest transientIf inactivated, damage accumulates

activate apoptosis program”