Paroxysmal nocturnal hemoglobinuria
Lack of CD55/59 –> No GPI thus complement-mediated susceptibility and pancyotpeniaDx:-Ham’s test: Only PNH cells lyse-Sugar water test: Only PNH cells lyse-Flow cyst: CD55/59 negativeTreat: Steroid
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Paroxysmal nocturnal hemoglobinuria
Lack of CD55/59 –> No GPI thus complement-mediated susceptibility and pancyotpeniaDx:-Ham’s test: Only PNH cells lyse-Sugar water test: Only PNH cells lyse-Flow cyst: CD55/59 negativeTreat: Steroid