Primary vs secondary adrenal insufficiency,”Both-Low cortisol –> hTN, low Na, weight loss, hypoglycemiaPrimary (addison)-High ACTH-Skin pigmentation-Low aldosterone

Primary vs secondary adrenal insufficiency,”Both-Low cortisol –> hTN, low Na, weight loss, hypoglycemiaPrimary (addison)-High ACTH-Skin pigmentation-Low aldosterone

high renin-High KSecondary-Low to normal ACTH-No skin pigmentation-Normal aldosterone thus normal KDx-Low plasma cortisol-Followup with ACTH to determine if primary vs secondaryTreat-Primary: Glucocorticoids (hydrocortisone or prednisone) + mineralcorticoid (fludrocortisone)-Secondary: Just GC”