Rb,”Retinoblastoma Tumor Suppressornormally binds to E2F and keeps it from activating Cyclin E and A when Cyclin D accumulates, it binds to CDK, which phosphorylates Rb, which released E2F–>which can no activate transcription(for cyclin A
cyclin E and itself–>autoproliferative mode)Now generating more E2F than non-phosphorylated Rb–> going to quickly run out of Rb tumor suppressor that keeps breaks on E2Fcommitted to go through one round of mitosis…”