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Read moreTag: Microcell Biology
“HW: Which one of the following would you first need to determine is uniquely expressed in a particular tumor cel in order to change a “”blocking”” monoclonal antibody like Herceptin or Cetuximab into a chemotherapeutic “”smart bomb”” to target just that cell?”
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Read moreGleevec
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Read moreCetuximab
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Cetuximab antibody similar to Herceptin[…]
Read moreAxitinib,”effectively inhibits Bcr-Abl 1 (t315I) with a distinct binding conformationgood inhibitor of -S receptor; responds to release of vascular growth factorPeriodically monitor circulating DNA treated w/ Gleevec, and as soon as you see mutation
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Axitinib,”effectively inhibits Bcr-Abl 1 (t315I)[…]
Read moreGDP,”(Guanosine di-phosphate)form of G proteingets promoted and released by Ras GEFswitch 2 traps it inside G protein(concentration in cytosol very low, and G proteins have very low affinity for it, but high affinity for GTP–>why we need GEF)(alpha helical Sos displaces switch 2, allowing it to diffuse away
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Read more“HW: Cetuximab binds to the EGF receptor (EGFR) and it’s initially effective in treating certain metastatic colon cancers when combined with radiation or other chemotherapies. However, over time, these tumor cells frequently become resistant to Cetuximab treatment. Which of the following mutational events is most frequently associated w/ the emergence of Cetuximab resistance?”,”Any one of G11
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Read moreVegF
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.VegF What cells release when[…]
Read moreRaf,”normally inactive protein kinase–> has internal regulatory domain, pair of phosphates, it’s tumor suppressor is 14-3-3 (normally keeps it inactive)turned on by binding to Rasgoing to activate kinase cascade(but still no 2nd messengers)When MAPK activated
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Raf,”normally inactive protein kinase–> has[…]
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