Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: Which graphs depict the[…]
Read moreTag: Microcell Biology
HW: Which FRET profile would tell you that a tumor cell is expressing the Vemurafenib resistant form of B-Raf onco-kinase?
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: Which FRET profile would[…]
Read moreHER1,”one of the “”normal”” oneslargest
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HER1,”one of the “”normal”” oneslargest[…]
Read moreCyclin D,”necessary for quiescent (non-proliferative) cells into G0 to “”re-enter”” the cell cycleactivation of Cyclin D transcription is one of the “”ultimate”” targets of the RTK pathwayaccumulation of cyclin D, binds to CDK
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Cyclin D,”necessary for quiescent (non-proliferative)[…]
Read moreWarber Effect,”Cancer cells going through glycolysis, convert most carbon to lactate (most lactate gets excreted from the cells)Person intakes a lot of Vitamin C (taking advantage of phenotype Ras driven cancer cells) Glutaphine immediately going to be reduced, but putting a high concentration of itgoing to have pleiotropic affects in cellscell becomes depleted of reduced glutaphine, and also w/ NADPHnow becomes oxidized environmentstart forming disulfide bonds in cytosol that shouldn’t be thereReactive oxygen species come in and damage DNA (severe damage)–>going to shut glycolysis down, has to switch over to mitochondria in oxidative phosphorylation to generate ATP (cell starting to starve itself
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Warber Effect,”Cancer cells going through[…]
Read moreHER4,”one of the “”normal”” onespredominately involved in nerve growth regeneration
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HER4,”one of the “”normal”” onespredominately[…]
Read moreE2F,”normally kept inactive by Rb tumor suppressor, but when Rb gets phosphorylated, it releases E2F to become active (generates more E2F than non-phosphorylated Rb–>lead to autoproliferation)activates Cyclin E transcription
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.E2F,”normally kept inactive by Rb[…]
Read moreHW: Were Linus Pauling’s views on the anti-cancer benefits of Vitamin C megadoses correct after all? What enables DHA to be selectively targeted into these cancer cells and what explains its cytotoxicity?,”DHA is transported into the cells by overexpressed GLUT1 transporters. DHA depletes cytosolic reduced glutathione (GSH) increasing levels of reactive oxygen species (ROS) that damage proteins and DNA and inhibiting glyceraldehyde 3-phosphate dehydrogenase (GADPH), thereby inhibiting glycolysis and ATP production
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Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HER3 Responds to neurotropic growth[…]
Read moreRb,”Retinoblastoma Tumor Suppressornormally binds to E2F and keeps it from activating Cyclin E and A when Cyclin D accumulates, it binds to CDK, which phosphorylates Rb, which released E2F–>which can no activate transcription(for cyclin A
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Rb,”Retinoblastoma Tumor Suppressornormally binds to[…]
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