Mechanism of NRTIs,”Competitively inhibit reverse transcriptase by lacking 3’OH group. All are nucleosides and require phosphrylation to be active except tenofovir.ZDV is used in pregnancy. Toxicity = bone marrow suppression, peripheral neuropathy, megoblastic anemia (ZDV), pancreatitis (ddl) Abacavir (ABC)Didanosine (ddl) Emtricitabine (FTC)Lamivudine (3TC)Stavudine (d4T)Tenofovir (TDF)Zalcitabine (ddC)Zidovudine (ZDV
AZT)”