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“HW: Ribonucleotide reductase (RR) and the mitochondrial pore protein, BAX, are two p53 target genes. What two compondents in the p53-dependent “”life or death”” decision do RR and BAX regulate?”
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.“HW: Ribonucleotide reductase (RR) and[…]
Read moreMissense Mutations,”two consequences: P53 unable to bind to DNA
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Missense Mutations,”two consequences: P53 unable[…]
Read moreTP53 Mutation
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.TP53 Mutation …
Read moreY220C
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Read moreHow dominant-negative mutations caused p53 to also be identified as an oncogene,”most p53 mutations eliminate DNA binding and destabilize the protein (mutant protein is functionally “”invisible””)BUT since p53 functions as a tetramer, some mutations that eliminate p53 function (transactivation), also inactivate tetramers containing only 1 mutant subunitIf cells contain equivalent amounts of wild-type and d-n mutant forms of p53 protein
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.How dominant-negative mutations caused p53[…]
Read moreHW: What are the most common mutations associated with a p53 tumor suppressor gene that are implicated in the majority of human cancers?
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: What are the most[…]
Read moreHW: Which of the following suppressors was thought to be an oncogene when it was initially discovered?
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: Which of the following[…]
Read more“Normal vs “”transformed”” cells”
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.“Normal vs “”transformed”” cells” normal[…]
Read moreProfactory requirements
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Profactory requirements normal cells only[…]
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