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General characteristics of paroxysmal nocturnal hemoglobinuria,”Acquired – affects cells of all blood lineages Deficiency of anchor proteins (CD55, CD59) that link complement inactivating proteins to blood cell membranes. Results in susceptibility to complement-mediated lysis of RBCs
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Read moreClinical features of PNH,”Elevated LDH Intravascular hemolysis Normochromic normocytic anemiaPancytopeniaThromboses of venous systemMay evolve to aplastic anemia, myelodysplasia, myelofibrosis, acute leukemia Abdominal
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Clinical features of PNH,”Elevated LDH[…]
Read moreHam test,”Patient cells are acidified serum, triggering the alternative complement pathway
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Read moreSugar water test,”Patient’s serum mixed in sucrose. In PNH
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Read moreNL platelet counts,”150,000-400
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.NL platelet counts,”150,000-400 000″
Read moreClassification of platelet disorders
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Read moreHIT type 1,”Heparin directly causes platelet aggregation; seen <48 hours after initiating heparin
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HIT type 1,”Heparin directly causes[…]
Read moreHIT type 2
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HIT type 2 Heparin induces[…]
Read moreITP characteristics,”IgG coats and damages platelets, which are then removed by splenic macrophages. Acute form: seen in children, preceded by viral infection, usually self limitedChronic form: usually in adults
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.ITP characteristics,”IgG coats and damages[…]
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