What are the etiologies of adverse drug reactions?,”ABCDEType A – Augmented. Dose dependent and predictable from the known pharmacology of the medication (75% of all ADR)Type B – Bizarre. Idiosyncratic or immunologic, unrelated to pharmacology (anaphylaxis, MH, etc). NEVER USE AGAIN.Type C – Chronic. Cumulative dose related (e.g. adrenal insufficiency). Type D – Delayed. Late effects (E.g. teratogenic, carcinogenic, tardive dyskinesia). Type E – End of use. Withdrawal (e.g. opioids). Therefore

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What are absolute contraindications to estrogen therapy?,”Top-down anatomical approach: Neuro – Migraine WITH focal neurological symptomsVascular1. Smoker > 35 yo2. HTN (sBP > 160, dBP > 100)3. DM with micro/macrovascular complications4. Clots – Hx of VTE, CVA, ischemic heart diseaseBreasts1. Postpartum (<6 weeks and breast feeding)2. Breast CancerLiver - Cirrhosis

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