Bcr-Abl Oncokinase,”Abl gene is on chromosome 9, tightly regulated, over on chromosome 22 is innocuous gene called BCR. Doesn’t do anything w/ any consequence except that it’s always expressedReciprocal chromosomal translocation…lower region on chromosome 22 hops on chromosome 9Makes chimeric protein on Bcr/Abl expressed all the time

Bcr-Abl Oncokinase,”Abl gene is on chromosome 9, tightly regulated, over on chromosome 22 is innocuous gene called BCR. Doesn’t do anything w/ any consequence except that it’s always expressedReciprocal chromosomal translocation…lower region on chromosome 22 hops on chromosome 9Makes chimeric protein on Bcr/Abl expressed all the time

so now going to get Ras dependent signaling that causes proliferation in the cellsDue to translocationResponsible for 10% of Leukemias”