Polyarteritis Nodosa,”Affects medium sized vessels of NS and GI tract Associated w. hep B, HIV and drug reactionsPMN invasion of all layers and fibroid necrosis + intimal proliferation lead to reduced luminal area –> ischemia, infarction, aneurysmsRosemary sign HTN, mononeuritic multiplex, livedo reticularis Rx with CST and cyclophosphamide if severe

Polyarteritis Nodosa,”Affects medium sized vessels of NS and GI tract Associated w. hep B, HIV and drug reactionsPMN invasion of all layers and fibroid necrosis + intimal proliferation lead to reduced luminal area –> ischemia, infarction, aneurysmsRosemary sign HTN, mononeuritic multiplex, livedo reticularis Rx with CST and cyclophosphamide if severe

poor prognosis”