Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Chimeric Proteins occur naturally; immune[…]
Read moreTag: Microcell Biology
HER2
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Read moreEGF receptor (epidermal growth factor)
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.EGF receptor (epidermal growth factor)[…]
Read moreChromosomal translocation,”shuffling between gene chromosomes1) will change expression of that gene2) going to make a new proteintake protein of one chromosome, hook it up to gene of another chromosome
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Chromosomal translocation,”shuffling between gene chromosomes1)[…]
Read moreHW: How can normal HER2 promote cell proliferation even though it does not directly bind to any extracellular growth factors?,”Answer: None of the abovepromote tumor proliferation for 2 reasons: 1) Her2 can form heterodimers with any other Her family members (1, 3, 4). This is going to sensitize the cell to basically grow at very low extracellular concentrations of EGF that normally wouldn’t be enough to activate Her1 or Her4 homodimers. Her2 coming in and forming and activating a large number of other receptors that would normally be monomeric. The other thing that happens, new insight, when you overexpress Her2
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: How can normal HER2[…]
Read moreHW: What types of mutational events can generate RTKs that promote proliferation in the complete absence of extracellular growth factors?,”A, B, & CGene amplification, missense mutations
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Read moreBcr/Abl,”normally well-behaved kinase called Abl. Comes into Ras. It is a tyrosine kinase that can autophosphorylate when it gets switched on, and can activate Ras w/o an extracellular signal. Can be activated within the cytosol, once phosphorylated it binds…Going down signaling pathway, but starting within the cellAbl normally well regulated
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Bcr/Abl,”normally well-behaved kinase called Abl.[…]
Read moreSos,”(binding site for GRB2 protein)GEF for Ras (which is monomeric G protein)promotes GDP (same thing G coupled protein does)alters the conformations of 2 switch regions to promote GDP releasehas an alpha-helical domain–>displaces switch 2 (pushes down)
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Sos,”(binding site for GRB2 protein)GEF[…]
Read moreHerceptin,”promising new immunotherapy for metastatic breast canceralpha-HER2 antibody binds receptor, blocks EGF binding & increases HER2 endocytosismonoclonal antibody that recognizes that the epitope is going to be the extracellular domain of Her2; going to prefererntially target the tumor cells b/c they are going to have the highest concentration of Her2 on the plasma membraneblocking antibody (increase endocytosis–> not only prevents binding of ligand
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Read moreBcr-Abl Oncokinase,”Abl gene is on chromosome 9, tightly regulated, over on chromosome 22 is innocuous gene called BCR. Doesn’t do anything w/ any consequence except that it’s always expressedReciprocal chromosomal translocation…lower region on chromosome 22 hops on chromosome 9Makes chimeric protein on Bcr/Abl expressed all the time
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Bcr-Abl Oncokinase,”Abl gene is on[…]
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