Which cells does pheochromocytoma arise from and what is the 10% rule of pheochromocytoma?

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Which cells does pheochromocytoma arise from and what is the 10% rule of pheochromocytoma?

Tumour of chromaffin cells of adrenal medulla10% will be:Bilateral.Extra-adrenal.Multiple.Malignant.Familial.