Wilson disease,”AR mutation in ATP7B Impaired copper excretion into bile and incorporation of Cu into ceruloplasminCu accumulates in hepatocytes and kills them then links into various organs –> cornea, brain, kidney Labs: decreased ceruloplasminTreatment: d-penicillamine, zinc (prevents Cu uptake)

Wilson disease,”AR mutation in ATP7B Impaired copper excretion into bile and incorporation of Cu into ceruloplasminCu accumulates in hepatocytes and kills them then links into various organs –> cornea, brain, kidney Labs: decreased ceruloplasminTreatment: d-penicillamine, zinc (prevents Cu uptake)

liver transplant”