Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: (Fret Graphs)You observe the[…]
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BIO205
HW: A report published in the April 21 issue of Cell shows that the small molecule rigosertib prevents Ras-dependent activation of Raf and thereby blocks cell proliferation. Which of the following oncogenes would have their proliferative signals blocked by rigosertib treatment indicating that cancers arising from any one of these oncogenes could potentially be treated with this molecule?,”HER2, Neu, ErbB
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: A report published in[…]
Read moreTumor Suppressors,”keep proto-oncogenes in checkinhibit cell survival or proliferationex) NF1, p53**, Rb, P21cipeffect of mutation: loss-of-function mutations allow unregulated cell proliferation and survivalmutations genetically recessivearise by deletion, point mutation
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Tumor Suppressors,”keep proto-oncogenes in checkinhibit[…]
Read moreHW: Which of the following possible CFP-donors would only bind to a potential YFP-acceptor when the YFP-acceptor is phosphorylated?,”CFP-GRB2
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: Which of the following[…]
Read moreOncogenic B-Raf,”In normal cells, signal activaged RAS recruits B-Raf to the cell membrane and activates its kinase domain through dimerization. Active B-Raf, in turn, triggers MEK and ERK protein kinases, through phosphorylation (P)
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Oncogenic B-Raf,”In normal cells, signal[…]
Read moreCaretaker Genes,”repair or prevent DNA damageex) BRCA1, BRCA2, XPgene products: DNA-repair-enzymeseffect of mutation: loss-of-function mutations allow mutations to accumulatemutations genetically recessivearise by deletion, point mutation
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Caretaker Genes,”repair or prevent DNA[…]
Read moreHW: You observe the following activity/FRET profiles upon the addition and subsequent removal of EGF to a mutant cell line. RTK activity of HER1=1. FRET profile of CFP-GRB2 + YFP-SOS =1. FRET profile of CFP-Raf + YFP-14-3-3 =7. What would be the activity profile for MEK in these cells?
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: You observe the following[…]
Read moremutant B-RafV600E
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.mutant B-RafV600E constitutively sends signals[…]
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Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HER Human Epidermal Growth Factor
Read moreHW: Which graphs depict the FRET profiles for CFP-GRB2 + YFP-HER1 & CFP-GRB2 +YFP-SOS upon the addition and subsequent removal of EGF to normal cells
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: Which graphs depict the[…]
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