Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.VegF What cells release when[…]
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BIO205
Raf,”normally inactive protein kinase–> has internal regulatory domain, pair of phosphates, it’s tumor suppressor is 14-3-3 (normally keeps it inactive)turned on by binding to Rasgoing to activate kinase cascade(but still no 2nd messengers)When MAPK activated
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Raf,”normally inactive protein kinase–> has[…]
Read moreRas^D,”mutant oncogene lacks GTPase activity, associated w/ numerous cancersconstitutively activeis a dominate active (aka dominant gain-of-function) alleleloses GTPase activity by altering any 1 of G12, G13, A59, G13, Q61
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Ras^D,”mutant oncogene lacks GTPase activity,[…]
Read moreHW: Which of the following exemplifies how a single missense mutation can be sufficient to convert a proto-oncogene to an oncogene
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: Which of the following[…]
Read more14-3-3
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.14-3-3 tumor suppressor (normally keeps[…]
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Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.NF1 “tumor suppressor gene that[…]
Read moreMyc,”translocation of c-myc gene from chromosome 8 to 14 places it under transcriptional control of a strong immunoglobulin gene transcriptional enhancer(don’t need growth factor, elevated expression…)overexpression of c-myc in these B cells causes Burkitt’s lymphomagoing to be self-sustaining b/c last step is activatedlast step in RTK signaling before activating Cyclin D (trips the cycle out of G0), transcription activated, make a proteindifficult to target(activate transcription of myc, RNA out of cytoplasm, comes back into nucleus, that activates Cyclin D–>once synthesis begins
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Myc,”translocation of c-myc gene from[…]
Read moreMAPK,”Mitogen-activated Extracurricular signal-regulated Kinasedual-specificity Kinase (threonine, tyrosine)when activated, will rephosphorylate Rafcomes back and shuts Raf back off, goal is to not let proliferative pathway go any further than it already is(If MAPK can phosphorylate, it will shut off)when active, it forms homodimer sort of like PKA, it phosphorylates actual proteins in the cell, a huge number, only looking at a small subset necessary for the cell to proliferateand can come right to the nucleuswithin the nucleus, cohort of DNA transcription factors already there
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.MAPK,”Mitogen-activated Extracurricular signal-regulated Kinasedual-specificity Kinase[…]
Read moreHW: Which MAPK activity profile would you observe upon the addition and subsequent removal of EGF to a particular cell line that would distinguish if it’s expressing Ras^D allele or lacks NF1 activity (NF1-)?
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: Which MAPK activity profile[…]
Read moreProto-Oncogenes,”the cancer genesnormal genes that have normal proliferation but are going to go rogue and become oncogenespromote cell survival or proliferationex) HER2, Ras, Raf, Abl, Myceffect of mutation: gain-of-function mutations allow unregulated cell proliferation and survivalmutations genetically dominantarise by point mutation, chromosomal translocation
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Proto-Oncogenes,”the cancer genesnormal genes that[…]
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