Mutation in G6PD def,”X-linked recessive so primarly affects men Deficiency leads to accumulation of unneutralized H202 which denatures Hgb, precipitating Heinz body formation that attack to RBC membranes which reduce flexibility, destroyed by spleen A variant: older RBCs are destroyed, young are spared. Usually triggered by infection or by rdugs Severe form: usually in Mediterranean descent

Mutation in G6PD def,”X-linked recessive so primarly affects men Deficiency leads to accumulation of unneutralized H202 which denatures Hgb, precipitating Heinz body formation that attack to RBC membranes which reduce flexibility, destroyed by spleen A variant: older RBCs are destroyed, young are spared. Usually triggered by infection or by rdugs Severe form: usually in Mediterranean descent

young and old RBCs destroyed”