Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: Were Linus Pauling’s views[…]
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Warber Effect,”Cancer cells going through glycolysis, convert most carbon to lactate (most lactate gets excreted from the cells)Person intakes a lot of Vitamin C (taking advantage of phenotype Ras driven cancer cells) Glutaphine immediately going to be reduced, but putting a high concentration of itgoing to have pleiotropic affects in cellscell becomes depleted of reduced glutaphine, and also w/ NADPHnow becomes oxidized environmentstart forming disulfide bonds in cytosol that shouldn’t be thereReactive oxygen species come in and damage DNA (severe damage)–>going to shut glycolysis down, has to switch over to mitochondria in oxidative phosphorylation to generate ATP (cell starting to starve itself
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review. Warber Effect,”Cancer cells going[…]
Read moreHW: Which FRET profile would tell you that a tumor cell is expressing the Vemurafenib resistant form of B-Raf onco-kinase?
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: Which FRET profile would[…]
Read moremutant B-RafV600E
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.mutant B-RafV600E constitutively sends signals[…]
Read moreOncogenic B-Raf,”In normal cells, signal activaged RAS recruits B-Raf to the cell membrane and activates its kinase domain through dimerization. Active B-Raf, in turn, triggers MEK and ERK protein kinases, through phosphorylation (P)
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Oncogenic B-Raf,”In normal cells, signal[…]
Read moreHW: A report published in the April 21 issue of Cell shows that the small molecule rigosertib prevents Ras-dependent activation of Raf and thereby blocks cell proliferation. Which of the following oncogenes would have their proliferative signals blocked by rigosertib treatment indicating that cancers arising from any one of these oncogenes could potentially be treated with this molecule?,”HER2, Neu, ErbB
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: A report published in[…]
Read moreHW: Which MAPK activity profile would you observe upon the addition and subsequent removal of EGF to a particular cell line that would distinguish if it’s expressing Ras^D allele or lacks NF1 activity (NF1-)?
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: Which MAPK activity profile[…]
Read moreNF1
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.NF1 “tumor suppressor gene that[…]
Read moreRas^D,”mutant oncogene lacks GTPase activity, associated w/ numerous cancersconstitutively activeis a dominate active (aka dominant gain-of-function) alleleloses GTPase activity by altering any 1 of G12, G13, A59, G13, Q61
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Ras^D,”mutant oncogene lacks GTPase activity,[…]
Read more“HW: Cetuximab binds to the EGF receptor (EGFR) and it’s initially effective in treating certain metastatic colon cancers when combined with radiation or other chemotherapies. However, over time, these tumor cells frequently become resistant to Cetuximab treatment. Which of the following mutational events is most frequently associated w/ the emergence of Cetuximab resistance?”,”Any one of G11
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.“HW: Cetuximab binds to the[…]
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