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“HW: Which one of the following would you first need to determine is uniquely expressed in a particular tumor cel in order to change a “”blocking”” monoclonal antibody like Herceptin or Cetuximab into a chemotherapeutic “”smart bomb”” to target just that cell?”
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review. “HW: Which one of[…]
Read moreHerceptin,”promising new immunotherapy for metastatic breast canceralpha-HER2 antibody binds receptor, blocks EGF binding & increases HER2 endocytosismonoclonal antibody that recognizes that the epitope is going to be the extracellular domain of Her2; going to prefererntially target the tumor cells b/c they are going to have the highest concentration of Her2 on the plasma membraneblocking antibody (increase endocytosis–> not only prevents binding of ligand
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Herceptin,”promising new immunotherapy for metastatic[…]
Read moreHW: What types of mutational events can generate RTKs that promote proliferation in the complete absence of extracellular growth factors?,”A, B, & CGene amplification, missense mutations
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Read moreEGF receptor (epidermal growth factor)
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.EGF receptor (epidermal growth factor)[…]
Read moreRb,”Retinoblastoma Tumor Suppressornormally binds to E2F and keeps it from activating Cyclin E and A when Cyclin D accumulates, it binds to CDK, which phosphorylates Rb, which released E2F–>which can no activate transcription(for cyclin A
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Rb,”Retinoblastoma Tumor Suppressornormally binds to[…]
Read moreE2F,”normally kept inactive by Rb tumor suppressor, but when Rb gets phosphorylated, it releases E2F to become active (generates more E2F than non-phosphorylated Rb–>lead to autoproliferation)activates Cyclin E transcription
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.E2F,”normally kept inactive by Rb[…]
Read moreCyclin D,”necessary for quiescent (non-proliferative) cells into G0 to “”re-enter”” the cell cycleactivation of Cyclin D transcription is one of the “”ultimate”” targets of the RTK pathwayaccumulation of cyclin D, binds to CDK
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Read moreHW: Which graphs depict the FRET profiles for CFP-GRB2 + YFP-HER1 & CFP-GRB2 +YFP-SOS upon the addition and subsequent removal of EGF to normal cells
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: Which graphs depict the[…]
Read moreHW: You observe the following activity/FRET profiles upon the addition and subsequent removal of EGF to a mutant cell line. RTK activity of HER1=1. FRET profile of CFP-GRB2 + YFP-SOS =1. FRET profile of CFP-Raf + YFP-14-3-3 =7. What would be the activity profile for MEK in these cells?
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: You observe the following[…]
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