Protease inhibitors,”Inhibited protease (pol gene) which cleaves polypeptide produces. All end in -navirToxicity: hyperglycemia, hyperlipidemia, GI intolerance
lipodystrophy AtazanavirDarunavirfosamprenavirIndinavir (cyrstal induced nephropathy)Ritonavir (boost by inhibiting p450)Saquinavir (boost by inhibiting p450)”