Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Ras^D,”mutant oncogene lacks GTPase activity,[…]
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NF1
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.NF1 “tumor suppressor gene that[…]
Read moreHW: Which MAPK activity profile would you observe upon the addition and subsequent removal of EGF to a particular cell line that would distinguish if it’s expressing Ras^D allele or lacks NF1 activity (NF1-)?
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: Which MAPK activity profile[…]
Read moreHW: A report published in the April 21 issue of Cell shows that the small molecule rigosertib prevents Ras-dependent activation of Raf and thereby blocks cell proliferation. Which of the following oncogenes would have their proliferative signals blocked by rigosertib treatment indicating that cancers arising from any one of these oncogenes could potentially be treated with this molecule?,”HER2, Neu, ErbB
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: A report published in[…]
Read moreOncogenic B-Raf,”In normal cells, signal activaged RAS recruits B-Raf to the cell membrane and activates its kinase domain through dimerization. Active B-Raf, in turn, triggers MEK and ERK protein kinases, through phosphorylation (P)
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Oncogenic B-Raf,”In normal cells, signal[…]
Read moremutant B-RafV600E
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.mutant B-RafV600E constitutively sends signals[…]
Read moreHW: Which FRET profile would tell you that a tumor cell is expressing the Vemurafenib resistant form of B-Raf onco-kinase?
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: Which FRET profile would[…]
Read moreWarber Effect,”Cancer cells going through glycolysis, convert most carbon to lactate (most lactate gets excreted from the cells)Person intakes a lot of Vitamin C (taking advantage of phenotype Ras driven cancer cells) Glutaphine immediately going to be reduced, but putting a high concentration of itgoing to have pleiotropic affects in cellscell becomes depleted of reduced glutaphine, and also w/ NADPHnow becomes oxidized environmentstart forming disulfide bonds in cytosol that shouldn’t be thereReactive oxygen species come in and damage DNA (severe damage)–>going to shut glycolysis down, has to switch over to mitochondria in oxidative phosphorylation to generate ATP (cell starting to starve itself
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Warber Effect,”Cancer cells going through[…]
Read moreHW: Were Linus Pauling’s views on the anti-cancer benefits of Vitamin C megadoses correct after all? What enables DHA to be selectively targeted into these cancer cells and what explains its cytotoxicity?,”DHA is transported into the cells by overexpressed GLUT1 transporters. DHA depletes cytosolic reduced glutathione (GSH) increasing levels of reactive oxygen species (ROS) that damage proteins and DNA and inhibiting glyceraldehyde 3-phosphate dehydrogenase (GADPH), thereby inhibiting glycolysis and ATP production
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: Were Linus Pauling’s views[…]
Read moreChimeric Proteins
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Chimeric Proteins occur naturally; immune[…]
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