Author: mfadmin

Bcr/Abl,”normally well-behaved kinase called Abl. Comes into Ras. It is a tyrosine kinase that can autophosphorylate when it gets switched on, and can activate Ras w/o an extracellular signal. Can be activated within the cytosol, once phosphorylated it binds…Going down signaling pathway, but starting within the cellAbl normally well regulated

Biology

Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Bcr/Abl,”normally well-behaved kinase called Abl.[…]

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Bcr-Abl Oncokinase,”Abl gene is on chromosome 9, tightly regulated, over on chromosome 22 is innocuous gene called BCR. Doesn’t do anything w/ any consequence except that it’s always expressedReciprocal chromosomal translocation…lower region on chromosome 22 hops on chromosome 9Makes chimeric protein on Bcr/Abl expressed all the time

Biology

Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Bcr-Abl Oncokinase,”Abl gene is on[…]

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Myc,”translocation of c-myc gene from chromosome 8 to 14 places it under transcriptional control of a strong immunoglobulin gene transcriptional enhancer(don’t need growth factor, elevated expression…)overexpression of c-myc in these B cells causes Burkitt’s lymphomagoing to be self-sustaining b/c last step is activatedlast step in RTK signaling before activating Cyclin D (trips the cycle out of G0), transcription activated, make a proteindifficult to target(activate transcription of myc, RNA out of cytoplasm, comes back into nucleus, that activates Cyclin D–>once synthesis begins

Biology

Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Myc,”translocation of c-myc gene from[…]

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