Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: Which graphs depict the[…]
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Cyclin D,”necessary for quiescent (non-proliferative) cells into G0 to “”re-enter”” the cell cycleactivation of Cyclin D transcription is one of the “”ultimate”” targets of the RTK pathwayaccumulation of cyclin D, binds to CDK
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Cyclin D,”necessary for quiescent (non-proliferative)[…]
Read moreE2F,”normally kept inactive by Rb tumor suppressor, but when Rb gets phosphorylated, it releases E2F to become active (generates more E2F than non-phosphorylated Rb–>lead to autoproliferation)activates Cyclin E transcription
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.E2F,”normally kept inactive by Rb[…]
Read moreRb,”Retinoblastoma Tumor Suppressornormally binds to E2F and keeps it from activating Cyclin E and A when Cyclin D accumulates, it binds to CDK, which phosphorylates Rb, which released E2F–>which can no activate transcription(for cyclin A
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Rb,”Retinoblastoma Tumor Suppressornormally binds to[…]
Read moreEGF receptor (epidermal growth factor)
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.EGF receptor (epidermal growth factor)[…]
Read moreHW: What types of mutational events can generate RTKs that promote proliferation in the complete absence of extracellular growth factors?,”A, B, & CGene amplification, missense mutations
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.HW: What types of mutational[…]
Read moreHerceptin,”promising new immunotherapy for metastatic breast canceralpha-HER2 antibody binds receptor, blocks EGF binding & increases HER2 endocytosismonoclonal antibody that recognizes that the epitope is going to be the extracellular domain of Her2; going to prefererntially target the tumor cells b/c they are going to have the highest concentration of Her2 on the plasma membraneblocking antibody (increase endocytosis–> not only prevents binding of ligand
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Herceptin,”promising new immunotherapy for metastatic[…]
Read more“HW: Which one of the following would you first need to determine is uniquely expressed in a particular tumor cel in order to change a “”blocking”” monoclonal antibody like Herceptin or Cetuximab into a chemotherapeutic “”smart bomb”” to target just that cell?”
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.“HW: Which one of the[…]
Read moreCetuximab
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.Cetuximab antibody similar to Herceptin[…]
Read more“HW: Cetuximab binds to the EGF receptor (EGFR) and it’s initially effective in treating certain metastatic colon cancers when combined with radiation or other chemotherapies. However, over time, these tumor cells frequently become resistant to Cetuximab treatment. Which of the following mutational events is most frequently associated w/ the emergence of Cetuximab resistance?”,”Any one of G11
Average Rating 0 out of 5 stars. 0 votes.You must log in to submit a review.“HW: Cetuximab binds to the[…]
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